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目的探讨不同抗胆碱能化合物联合氯解磷定对沙林染毒兔的救治效果,为药物联合应用的合理救治方案提供依据。方法通过测定几种抗胆碱能化合物与氯解磷定单独或者联合应用对沙林染毒兔的防护比率,并结合动物救治过程中体内乙酰胆碱酯酶(AChE)和丁酰胆碱酯酶(BChE)活性恢复情况,确定疗效较好的可与氯解磷定联合应用的抗胆碱能化合物。结果阿托品、盐酸戊乙奎醚、氯解磷定单独应用时对中毒兔的防护比率均小于1.20;不同种类抗胆碱能药物与氯解磷定联合应用时,3种盐酸戊乙奎醚联合其他药物的防护比率均较2种阿托品联合其他药物的防护比率高,前者对动物的防护比率为3.68～3.80,后者对动物的防护比率为2.30～2.56。采用盐酸戊乙奎醚和贝那替秦与氯解磷定联合应用对沙林重度染毒兔的疗效为77.8%。结论采用盐酸戊乙奎醚和贝那替秦与氯解磷定联合应用对沙林染毒兔有较好的救治效果。
Objective To investigate the therapeutic effects of different anticholinergic compounds combined with chlorpheniramine on sarin-contaminated rabbits, and to provide evidence for the rational treatment of drug combination. Methods The protective ratios of several anticholinergic compounds and chlorophenanthroline alone or in combination on sarin-contaminated rabbits were determined. The protective effects of AChE and butyrylcholinesterase (AChE) BChE activity recovery, to determine the better curative effect with chlorpheniramine combination of anticholinergic compounds. Results The protective ratios of atropine, penehyclidine hydrochloride and chlorpheniramine when applied alone were less than 1.20 for poisoning rabbits. When different anticholinergic drugs were used in combination with chlorpromazine, the three penehyclidine hydrochloride combined The protective ratios of other drugs were higher than the other two kinds of atropine combined with other drugs, the former protection ratio of 3.68 to 3.80 for animals, the latter protection ratio for animals 2.30 ~ 2.56. The efficacy of penehyclidine hydrochloride and benazepine in combination with chlorpromazine was 77.8% for severe rabbits exposed to sarin. Conclusion Penehyclidine hydrochloride and benazepine combined with chlorophenanthroline can effectively treat rabbits exposed to sarin.