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目的探讨抗甲状腺药物对131I治疗甲状腺功能亢进症临床疗效的影响。方法回顾性分析我院收治的甲状腺功能亢进症患者112例,依据其治疗过程中是否给予抗甲状腺药物分为给药组(42例)、停药1月组(34例)和非给药组(36例);三组患者均给予131I治疗,比较三组患者临床疗效的区别。结果非给药组临床疗效明显优于其他两组(P<0.01、P<0.05);甲状腺激素FT3、FT4水平进行比较,非给药组明显优于其他两组(P<0.05)。结论抗甲状腺药物明显降低了131I治疗甲状腺功能亢进症的临床疗效,因此临床在选取治疗方法时,应分清主次,选取最佳的治疗方案。
Objective To investigate the effect of anti-thyroid drugs on the clinical efficacy of 131I in the treatment of hyperthyroidism. Methods One hundred and twelve patients with hyperthyroidism admitted to our hospital were retrospectively analyzed. According to whether antithyroid drugs were given in the course of treatment, they were divided into the treatment group (42 cases), the discontinuation group (34 cases) and the non-medication group (36 cases). The three groups of patients were given 131I treatment, the difference between the clinical efficacy of the three groups were compared. Results Compared with the other two groups, the clinical efficacy of non-administration group was significantly better than that of the other two groups (P <0.01, P <0.05). The levels of FT3 and FT4 in thyroid hormones were significantly higher than those in the other two groups (P <0.05). Conclusion Antithyroid drugs significantly reduce the clinical efficacy of 131I in the treatment of hyperthyroidism, so the clinical selection of treatment methods, we should distinguish between primary and secondary, select the best treatment.