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目的探讨女性癫痫发作频率与患者体内血清性激素水平的关系,为女性癫痫患者的临床治疗提供依据。方法以2012年9月至2016年7月期间就诊于甘肃省武威市凉州医院门诊的女性癫痫患者76例作为研究对象。按照癫痫发作频率不同分为高频率发作组(FA组)和低频率发作组(FB组),按照围经期/非围经期癫痫分为围经期发作组(PA组)和非围经期发作组(PB组)。比较不同组间患者4项血清性激素指标雌二醇、孕酮、睾酮、泌乳素水平。结果 FA组患者孕酮水平高于FB组,而泌乳素水平低于FB组,差异有统计学意义(P<0.05);两组间雌激素和睾酮水平比较,差异无统计学意义(P>0.05)。PA组患者孕酮水平高于FB组,而泌乳素水平低于PB组,差异有统计学意义(P<0.05);两组间雌激素和睾酮水平比较,差异无统计学意义(P>0.05)。PA组患者癫痫高频发作率高于PB组,差异有统计学意义(P<0.05)。结论女性癫痫发作与血清性激素水平密切相关。
Objective To investigate the relationship between the frequency of seizures in women and the levels of serum sex hormones in patients and provide the basis for the clinical treatment of female patients with epilepsy. Methods A total of 76 women with epilepsy who visited the Liangzhou Hospital of Wuwei City, Gansu Province from September 2012 to July 2016 were selected as the study objects. According to the different seizure frequency, the patients were divided into high-frequency seizure group (FA group) and low-frequency seizure group (FB group) according to seizure frequency. According to the perimenopausal seizure group (PA group) and non-seizure seizure group PB group). Four groups of serum sex hormones, estradiol, progesterone, testosterone and prolactin were compared among different groups. Results The level of progesterone in the FA group was higher than that in the FB group, while the level of prolactin was lower than that in the FB group (P <0.05). There was no significant difference in estrogen and testosterone levels between the two groups (P> 0.05). The level of progesterone in PA group was higher than that in FB group, while the level of prolactin was lower than that in PB group (P <0.05). There was no significant difference in estrogen and testosterone levels between the two groups (P> 0.05 ). The frequency of epileptic seizures in PA group was higher than that in PB group, with significant difference (P <0.05). Conclusion Female seizures are closely related to serum sex hormones.