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目的研究肝源性溃疡(HU)患者胃黏膜表皮生长因子(EGF)、前列腺素E2(PEG2)的表达及其意义。方法选取HU患者30例及肝硬化非HU、慢性胃炎、非溃疡性消化不良(NUD)患者各40例,行上消化道内镜检查,取胃窦及胃体黏膜组织各1块,用ELISA及RIA法分别检测EGF及PEG2含量。结果(1)HU患者胃黏膜EGF、PGE2含量明显低于肝硬化非HU患者。(2)HU患者胃黏膜EGF、PGE2含量明显低于慢性胃炎及NUD组,而后两者无明显差异。(3)HU患者胃黏膜EGF、PGE2含量与肝功能分级无关。结论(1)HU患者胃黏膜防御屏障减弱。(2)HU患者胃黏膜EGF、PGE2的降低参与HU的形成。
Objective To study the expression of gastric mucosal epidermal growth factor (EGF) and prostaglandin E2 (PEG2) in patients with liver-derived ulcer (HU). Methods Thirty patients with HU and 40 patients with non-HU, chronic gastritis and non-ulcer dyspepsia (NUD) were enrolled in this study. One upper gastrointestinal tract and one gastric mucosa were enrolled in upper gastrointestinal endoscopy. And RIA method were detected EGF and PEG2 content. Results (1) The levels of EGF and PGE2 in gastric mucosa of patients with HU were significantly lower than those of non-HU patients with cirrhosis. (2) The content of EGF and PGE2 in gastric mucosa of patients with HU was significantly lower than that of patients with chronic gastritis and NUD, but there was no significant difference between the two groups. (3) The gastric mucosal EGF and PGE2 levels in HU patients were not related to the grading of liver function. Conclusion (1) HU patients with gastric mucosal defense barrier weakened. (2) HU gastric mucosal EGF, PGE2 decreased involved in the formation of HU.