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了解成都市金牛区健康人群甲型H1N1流感抗体水平和甲型H1N1流感疫苗的免疫效果。方法分别于一个流行期前后检测3~11、12~17、18~60、>60岁4个年龄组健康人群甲型H1N1流感抗体水平,同时对部分人群分年龄组接种甲型H1N1流感疫苗,1月后检测其抗体水平。结果目前该区健康人群甲型H1N1流感抗体达到保护水平的比例为44.23%,GMT水平为1∶23.35,各年龄组差异有统计学意义(χ2=46.42,P<0.01;F=25.02,P<0.01),其中3~11、12~17岁组抗体水平较流行前期均有上升;甲型H1N1流感疫苗免疫后人群抗体阳转率为88.98%,GMT水平为1∶325.20,各年龄组之间差异有统计学意义(χ2=23.78,P<0.01;F=13.23,P<0.01),以311岁组水平较低。结论目前除1217岁组抗体水平较高外,其他年龄组保护性抗体比例仍较低,有必要对其继续加强甲型H1N1流感疫苗的宣传和接种。
To understand the antibody level of Influenza A (H1N1) and the immunization of Influenza A (H1N1) in healthy population in Jinniu District of Chengdu City. Methods The antibody levels of Influenza A (H1N1) virus in healthy population of 3 ~ 11, 12 ~ 17, 18 ~ 60, and 60 years old aged> 60 years were detected before and after an epidemic period. At the same time, some people were vaccinated with influenza A (H1N1) After 1 month the antibody level was tested. Results The proportion of influenza A (H1N1) antibody in healthy population in the district reached 44.23% and the GMT level was 1:23.35. The difference was statistically significant among all age groups (χ2 = 46.42, P <0.01; F = 25.02, P < 0.01). The levels of antibody in 3 ~ 11, 12 ~ 17 years old groups were all increased compared with the pre-epidemic stage. The antibody positive rate after vaccination with influenza A (H1N1) vaccine was 88.98% and the GMT level was 1: 325.20. The difference was statistically significant (χ2 = 23.78, P <0.01; F = 13.23, P <0.01), with a lower level at 311 years of age. Conclusion In addition to the high level of antibodies in 1217 age group, the proportion of protective antibodies in other age groups is still low, it is necessary to continue to enhance the promotion and vaccination of influenza A (H1N1) vaccine.