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反式-4-羟基-L-脯氨酸经酯化、保护、还原、SN2取代、Mitsunobu反应、醇解得到(2S,4S)-1-叔丁氧羰基-2- (N-叔丁氧羰基氨磺酰胺基)甲基-4-巯基吡咯烷(7),收率50．8％。7与(1R,5S,6S)-6-[(1R)-1-羟乙基]-2-二苯氧磷酰氧基-1-甲基-1-碳代-2-青霉烯-3-羧酸对硝基苄酯(8)缩合、脱保护,得到多尼培南,收率50．5％(以7计)。总收率接近26％(以反式-4-羟基-L-脯氨酸计)。
Esterification, protection, reduction, SN2 substitution, Mitsunobu reaction, and alcoholysis of trans-4-hydroxy-L-proline gave (2S, 4S) -1-tert-butoxycarbonyl-2- Carbonylsulfonamido) methyl-4-mercaptopyrrolidine (7) was obtained in a yield of 50.8%. 7 and (1R, 5S, 6S) -6 - [(1R) -1-hydroxyethyl] -2-diphenoxyphosphoryloxy-1-methyl-1-carba-2-penem- 3-carboxylic acid p-nitrobenzyl ester (8) was condensed and deprotected to give donepenem in a yield of 50.5% (at 7). The total yield is close to 26% (based on trans-4-hydroxy-L-proline).