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目的探讨逍遥散联合绒毛膜促性腺激素(human chorionic gonadotropin,HCG)治疗未破裂卵泡黄素化综合征(luteinized unruptured follicle syndrome,LUFS)的效果。方法选取2014年1月-2015年6月即墨市第二人民医院收治的120例LUFS患者,按照随机数字表法将患者随机分为对照组和观察组,每组60例。从月经第5天开始2组患者均服用促卵泡汤,同时监测卵泡情况,待卵泡成熟后,对照组予以10 000 IU HCG治疗;观察组予以逍遥散联合HCG治疗,HCG用法与对照组一致,逍遥散根据证型加减口服。比较2组患者的卵巢血流变化阻力指数(RI)、搏动指数(PI),雌二醇、促黄体生成素水平,排卵率、妊娠率及临床疗效。结果治疗后,2组患者的RI、PI均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组患者的雌二醇、促黄体生成素水平均明显高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05)。观察组的排卵率为72.79%,明显高于对照组的45.45%(P<0.05);妊娠率为43.33%,明显高于对照组的16.67%(P<0.05),差异有统计学意义。观察组的有效率为90.00%,明显高于对照组的66.67%(P<0.05),差异有统计学意义。结论在LUFS患者中应用逍遥散联合HCG治疗,能有效提高患者的排卵率及妊娠率,提高患者的血雌二醇、促黄体生成素水平,并有效改善患者的卵巢血流情况,具有重要的临床应用价值。
Objective To investigate the effect of Xiaoyao San combined with chorionic gonadotropin (HCG) on luteinized unruptured follicle syndrome (LUFS). Methods From January 2014 to June 2015, 120 patients with LUFS who were admitted to the Second People’s Hospital of Jimo City were randomly divided into control group and observation group according to random number table method, with 60 cases in each group. From the fifth day of menstruation, two groups of patients took follicular stimulation while monitoring follicular condition. After the follicles were mature, the control group was treated with 10 000 IU of HCG. The observation group was treated with Xiaoyaosan combined with HCG. HCG usage was consistent with that of the control group, Xiaoyaosan according to card type plus oral. Ovarian blood flow resistance index (RI), pulsatility index (PI), estradiol, luteinizing hormone, ovulation rate, pregnancy rate and clinical efficacy were compared between the two groups. Results After treatment, the RI and PI in both groups were significantly lower than those before treatment (P <0.05), and the observation group was lower than the control group (P <0.05). After treatment, the levels of estradiol and luteinizing hormone in both groups were significantly higher than those before treatment (P <0.05), and the observation group was significantly higher than the control group (P <0.05). The ovulation rate of the observation group was 72.79%, which was significantly higher than that of the control group (45.45%, P <0.05). The pregnancy rate was 43.33%, which was significantly higher than that of the control group (16.67%, P <0.05). The effective rate of the observation group was 90.00%, which was significantly higher than that of the control group (66.67%, P <0.05). The difference was statistically significant. Conclusions The application of Xiaoyaosan combined with HCG in patients with LUFS can effectively improve the ovulation rate and pregnancy rate, improve the level of serum estradiol and luteinizing hormone and improve the ovarian blood flow in patients with LUFS, which is of great importance Clinical application value.