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在神经发育过程中血小板源生长因子(platelet-derived growth factor,PDGF)家族调节细胞增殖、分化和迁移,且有神经保护作用。不同恶性程度的胶质瘤均有PDGF家族的过度表达,表达水平越高,肿瘤恶性程度越高。PDGF与PDGF受体(PDGF receptor,PDGFR)结合,激活一系列细胞内信号转导通路发挥多种细胞效应。利用逆转录病毒模型,介导PDGF过度表达能诱导恶性胶质瘤形成。PDGF调节肿瘤微环境,增加胶质瘤血管形成。阻断PDGF信号通路可抑制胶质瘤细胞生长,以PDGFR为作用靶点的抗胶质瘤药物为胶质瘤的治疗开辟新的途径。
Platelet-derived growth factor (PDGF) family regulates cell proliferation, differentiation and migration during neurodevelopment and has neuroprotective effects. The different degrees of malignancy glioma PDGF family over-expression, the higher the level of expression, the higher the degree of tumor malignancy. PDGF binds to PDGF receptor (PDGFR) and activates a series of intracellular signal transduction pathways to exert various cellular effects. Using retroviral model, mediated PDGF overexpression can induce malignant glioma formation. PDGF regulates tumor microenvironment and increases glioma angiogenesis. Blocking the PDGF signaling pathway can inhibit the growth of glioma cells, the anti-glioma drug targeting PDGFR opens up new avenues for the treatment of glioma.