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目的利用伤残调整寿命年(DALY)对2010-2012年山东省女性生殖系统三大恶性肿瘤的疾病负担进行综合评价。方法以该地区2010-2012年6个监测点的恶性肿瘤监测数据为基础,计算和分析乳腺癌、卵巢癌和宫颈癌的死亡率、发病率、DALY及DALY率,以此评价该地区的疾病负担。结果 2010-2012年山东省该地区乳腺癌年均粗死亡率为7.63/10万,发病率为32.04/10万,卵巢癌年均粗死亡率为2.00/10万,发病率为6.20/10万,宫颈癌年均粗死亡率为3.46/10万,发病率为7.95/10万;乳腺癌造成的疾病负担最重,是卵巢癌的4.24倍,宫颈癌的2.62倍;三大恶性肿瘤的DALY及DALY率均在逐年上升,低年龄组(45岁以下)DALY的上升速度较高年龄组更为明显,以宫颈癌最为显著;三大恶性肿瘤的疾病负担主要由早死所致,主要集中于30岁以后的人群,年轻化趋势明显。结论山东省该地区乳腺癌和宫颈癌的发病率和死亡率相对较高,已严重威胁妇女健康,应成为女性重点预防的恶性肿瘤。
Objective To evaluate the disease burden of three malignant tumors of the female reproductive system in Shandong Province from 2010 to 2012 by the disability adjusted life year (DALY). Methods Based on malignant tumor surveillance data at six surveillance sites in the region from 2010 to 2012, mortality, morbidity, DALY, and DALY rates were calculated and analyzed for breast, ovarian and cervical cancer to assess the prevalence of disease in the area burden. Results The average annual crude fatality rate of breast cancer in this area was 7.63 / lakh in 2010-2012, with an incidence rate of 32.04 / lakh. The annual average crude fatality rate was 2.00 / lakh and the incidence rate was 6.20 / lakh , The average annual death rate of cervical cancer was 3.46 / 100000, the incidence rate was 7.95 / 100000; breast cancer caused by the disease burden of the most is 4.24 times ovarian cancer, cervical cancer 2.62 times; three malignant tumors DALY And DALY rate are rising year by year, the low-age group (45 years of age) DALY increased more rapidly in the age group was more obvious, the most obvious cervical cancer; three major malignant tumor disease burden mainly due to premature death, mainly in the After 30 years of age, the trend of younger people is obvious. Conclusion The incidence and mortality of breast cancer and cervical cancer in Shandong Province are relatively high, which has seriously threatened the health of women and should become the focus of prevention of malignant tumors in women.