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对20例服用口服降糖药血糖控制不佳的T2DM患者随机进行不同时段的甘精胰岛素注射,观察24周。结果:两组在患者治疗前后FBG、HbA1c均明显降低,组间比在入组前,24周时各项指标的差异均无统计学意义(P>0.05)。且在实验观察期间均无一例低血糖发生。结论:无论在早餐前还是睡前注射甘精胰岛素联合口服降糖药都是安全有效的。
20 cases of T2DM patients taking oral hypoglycemic agents with poor glycemic control were randomized to receive glargine at different time points for 24 weeks. Results: The FBG and HbA1c in both groups were significantly decreased before and after treatment. There was no significant difference between the two groups before and 24 weeks after treatment (P> 0.05). And no hypoglycemia occurred during the experimental observation. Conclusion: It is safe and effective to inject insulin glargine and oral hypoglycemic agents before breakfast or before going to bed.