一、进展目前临床应用的抗肿癌药物大多属于细胞毒类药物,如氮芥类、乙烯亚胺类、氟尿嘧啶及顺氨铂类等,它们具有严重的毒付作用,均能抑制骨髓系统及细胞的免疫功能,导致患者继发性感染。限制了药物的应用及治疗效果,寻求非细胞毒抗肿瘤药物是药物研究的重大课题。一九七九年 Gosalvez 等发现 Thiop-roline(化学名为 Thiazolidine-4-Carboxylic First, the progress Currently most of the anti-cancer drugs are cytotoxic drugs such as nitrogen mustard, ethyleneimine, fluorouracil and cisplatin, etc., they have a serious drug-induced effects, both inhibit the bone marrow system and Immune function of cells, leading to secondary infection in patients. Limit the application of drugs and treatment effect, to seek non-cytotoxic antitumor drugs is a major issue in drug research. In 1979 Gosalvez et al found that Thiop-roline (chemical name Thiazolidine-4-Carboxylic