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目的探讨中枢神经系统感染患儿脑脊液(CSF)及血清S100B蛋白水平变化的意义。方法中枢神经系统感染患儿43例,其中结核性脑膜炎(简称结脑)12例,化脓性脑膜炎(简称化脑)9例,病毒性脑炎(简称病脑)22例。对照组患儿18例,其中先天性心脏病、肠套叠各6例,血管瘤、急性阑尾炎各3例。中枢神经系统患儿治疗前后留取血清及CSF标本,对照组术前留取血清及CSF标本。CSF及血清S100B蛋白水平均采用ELISA检测。结果治疗前结脑、化脑和病脑患儿CSF及血清S100B蛋白水平均明显高于对照组(Pa<0.001)。恢复期结脑、化脑和病脑患儿CSF及血清中S100B蛋白水平均明显下降,但结脑患儿CSF及血清S100B蛋白水平仍均高于对照组(Pa<0.01),而化脑组和病脑组患儿CSF及血清S100B蛋白水平与对照组比较差异均无显著性意义(Pa>0.05)。结论CSF及血清S100B蛋白水平测定有助于中枢神经系统感染患儿的诊断及预后的判断。
Objective To investigate the significance of cerebrospinal fluid (CSF) and serum S100B protein in children with central nervous system infection. Methods There were 43 cases of children with central nervous system infection, including 12 cases of tuberculous meningitis (tuberculous meningitis), 9 cases of purulent meningitis (melatonin) and 22 cases of viral encephalitis (meningitis). The control group of 18 children, including congenital heart disease, intussusception in 6 cases, hemangioma, acute appendicitis in 3 cases. Serum and CSF samples were collected before and after treatment in children with central nervous system, and serum and CSF samples were collected before operation in control group. CSF and serum S100B protein levels were detected by ELISA. Results The levels of CSF and serum S100B protein in patients with tuberculous meningitis and cerebral encephalopathy were significantly higher than those in the control group before treatment (Pa, 0.001). The level of S100B protein in CSF and serum of patients with convalescent brain, brain and brain were significantly decreased, but the levels of CSF and serum S100B in children with tuberculous meningitis were still higher than those in control group (Pa <0.01) There was no significant difference in the level of CSF and serum S100B protein between the control group and the control group (P> 0.05). Conclusion CSF and serum S100B protein levels are helpful to the diagnosis and prognosis of children with central nervous system infection.