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目的探讨恶性肿瘤患者血清OPN检测的临床意义。方法用酶联免疫吸附试验恶性肿瘤患者血清OPN水平。结果恶性肿瘤患者血清OPN水平明显高于正常对照组,差异有统计学意义(P<0.05)。恶性肿瘤患者手术前或放、化疗前的OPN水平显著高于手术后或放、化疗后患者和对照组,差异有统计学意义(P<0.05)。恶性肿瘤患者血清OPN水平还与淋巴结转移及远处转移有关。结论血清OPN检测可以作为恶性肿瘤患者的诊断、预后以及疗效评判的检测指标。
Objective To investigate the clinical significance of detecting serum OPN in patients with malignant tumor. Methods Serum OPN levels in patients with malignant tumors were tested by enzyme-linked immunosorbent assay. Results Serum OPN levels in patients with malignant tumors were significantly higher than those in normal controls (P <0.05). The level of OPN in patients with malignant tumor prior to surgery or before radiotherapy and chemotherapy was significantly higher than that after surgery or radiotherapy, and after chemotherapy, the difference was statistically significant (P <0.05). Serum OPN levels in patients with malignant tumor lymph node metastasis and distant metastasis. Conclusion Serum OPN can be used as a marker for the diagnosis, prognosis and therapeutic evaluation of patients with malignant tumor.