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分析成人急性淋巴细胞白血病(ALL)的MIC:分型与临床及预后的关系。方法:40例ALL。患者按常规骨髓涂片及细胞化学染色进行形态学分析,并用单克隆抗体间接免疫荧光法检测细胞免疫表型,用R显带技术分析13例的细胞遗传学。结果:FAB分型ALL-LI型3例,L2型35例,L3型2例。细胞免疫表型符合T细胞系ALL13例(伴髓系表达2例),B细胞系ALL21例(伴髓系表达4例),T/B细胞系共同表达ALL5例(伴髓系表达1例),未分化型急性白血病1例。13例中有8例核型异常。结论:ALL患者形态学检查结合免疫学和细胞遗传学综合分析,有利于明确白血病细胞克隆的来源,有利于估计预后,并指导治疗。
Analysis of MICs in Adult Acute Lymphoblastic Leukemia (ALL): Relationship with Clinical and Prognosis. Methods: 40 cases of ALL. The patients underwent routine bone marrow smear and cytochemical staining for morphological analysis. The immunophenotypes of the patients were detected by indirect immunofluorescence with monoclonal antibody. The cytogenetics of 13 patients was analyzed by R-banding technique. Results: FAB type ALL-LI type 3 cases, L2 type 35 cases, L3 type 2 cases. Cellular immunophenotypes were found in 13 cases of T cell line ALL (2 cases with myeloid lineage), 21 cases of B cell line ALL (4 cases of myeloid lineage), 5 cases of T cell line ALL (1 case of myeloid lineage) , Undifferentiated acute leukemia in 1 case. There were 8 cases of karyotype abnormalities in 13 cases. Conclusion: The morphological examination of ALL patients combined with immunological and cytogenetic analysis is helpful to identify the source of leukemic cell clones, to estimate the prognosis and to guide the treatment.