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本研究应用PCR技术对女性生殖道尖锐湿疣、可疑湿疣、假性湿疣、宫颈息肉、宫颈糜烂、慢性阴道炎等良性病变以及正常阴道组织进行HPV—DNA检测,结果HPV—DNA阳性检出率分别为 98.2％(56/57)、71.4％(15/21)、40.4％(19/47)、76.2％(16/21)、77.3％(17/22)、16％(4/25)和 10.7％(3/28),HPV6和 11型感染率分别占 85.7％(48/56)、80.0％(12/15)、26、3％(5/19)、50％(8/16)、17.6％(3/17)、25％(1/4)、0。提示,在对临床病变典型的病例进行HPV—DNA检测的同时,更应重视临床表现不典型甚至正常组织中 HPV—DNA的亚临床感染,这对生殖道恶性肿瘤的早期发现和预防有着重要意义。
In this study, HPV-DNA was detected by PCR in benign, condylomata, condylomatae, cervical polyp, cervical erosion, chronic vaginitis and normal vaginal tissues in female genital tract. The results showed that HPV-DNA positive rates were Were 76.2% (16/21), 77.3% (17/22), 16% (4/25), and 10.7 The infection rate of HPV6 and 11 were 85.7% (48/56), 80.0% (12/15), 26.3% (5/19), 50% (8/16), 17.6 % (3/17), 25% (1/4), 0. Tip, in the typical case of clinical lesions of HPV-DNA testing should pay more attention to clinical manifestations of atypical or even normal tissue HPV-DNA subclinical infection, which is of great importance to the early detection and prevention of genital malignancies .