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目的:探讨氨甲蝶呤(MTX)配伍米非司酮联合治疗非破裂型输卵管妊娠的效果。方法:米非司酮50 mg,口服,2次/d,用3 d,(第1、3、5天),氨甲蝶呤1 mg/kg,肌注,1次/d(第2、4、6天),其中第3、5、7天加用四氢叶酸0.1 mg/kg,肌注(氨甲喋呤用后24 h),单用MTX的病人设为对照组。结果:MTX配伍米非司酮联合治疗的成功率达94.58%,单用MTX成功率46.88%,差异有显著性(P<0.05)。结论:MTX配伍米非司酮联合治疗非破裂型输卵管妊娠安全有效,适用于生命体征平稳,无剧烈腹痛,-βHCG≤3 000 mIU/mL,盆腔包块较小者。
Objective: To investigate the effect of methotrexate (MTX) combined with mifepristone in the treatment of non-ruptured tubal pregnancy. Methods: Mifepristone 50 mg orally twice a day for 3 d (day 1, 3 and 5), methotrexate 1 mg / kg, intramuscular injection once per day 4 and 6 days). The patients in the 3rd, 5th and 7th days plus tetrahydrofolate 0.1 mg / kg, intramuscular injection (24 hours after methotrexate) and MTX alone were taken as the control group. Results: The success rate of MTX combined with mifepristone treatment was 94.58%, and the success rate of MTX alone was 46.88%. The difference was significant (P <0.05). CONCLUSION: MTX combined with mifepristone is safe and effective in the treatment of non-ruptured tubal pregnancy. It is suitable for patients with stable vital signs without severe abdominal pain, βHCG ≤3000 mIU / mL and pelvic mass.