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本文用双抗体放射免疫法研究了重症肌无力(MG)患者血清中乙酰胆硷受体抗体(AchRab)的变化;同时,用牛胶固素酶联免疫吸附试验检测了MG患者的循环免疫复合物(CIC)水平。结果发现:MG患者血清中存在着高滴度的AchRab,全身型MG患者的AchRab滴度高于眼型患者,在全身型MG组中,病情重度患者的AchRab滴度高于中度及轻度患者。对CIC水平的研究发现,MG患者的CIC水平高于正常人,全身型MG患者的CIC水平高于眼型患者,在全身型MG组中,病情重度患者的CIC水平高于中度及轻度患者。本研究还发现MG患者的AchRab滴度与CIC水平之间存在着明显的相关性。
In this paper, the changes of serum AchRab in patients with myasthenia gravis (MG) were studied by double antibody radioimmunoassay. At the same time, the AchRab in serum of patients with MG was detected by bovine colony-forming enzyme-linked immunosorbent assay (CIC) level. The results showed that there was a high titer of AchRab in the serum of patients with MG, and the AchRab titer of patients with systemic MG was higher than that of patients with ocular type. In the MG group, the AchRab titers in patients with severe disease were higher than those in moderate and mild patient. CIC levels found that MG patients with CIC levels higher than normal, patients with systemic MG CIC levels higher than those in the eye, in the systemic MG group, patients with severe disease CIC levels were higher than moderate and mild patient. This study also found a significant correlation between AchRab titers and CIC levels in MG patients.