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目的探讨小剂量激素联合霉酚酸酯与雷公藤多苷治疗儿童紫癜性肾炎的临床疗效。方法选择永州市中心医院南院2012年2月至2013年10月收治的儿童紫癜性肾炎患者68例,随机分成两组,对照组给予常规治疗,研究组在对照组的基础上实施小剂量激素联合霉酚酸酯与雷公藤多苷治疗,对两组的疗效进行深入比较。结果研究组治疗总有效率为91.2%,明显高于对照组(70.6%),差异有统计学意义(P<0.05)。研究组蛋白尿、血尿、水肿及高血压等症状的消失时间均明显短于对照组,差异有统计学意义(P<0.01)。结论小剂量激素联合霉酚酸酯与雷公藤多苷治疗儿童紫癜性肾炎疗效显著,有利于改善患者症状,且安全性好,值得推广及应用。
Objective To investigate the clinical effects of low dose hormone combined with mycophenolate mofetil and tripterygium glycosides in the treatment of purpuric nephritis in children. Methods Sixty-eight children with purpura nephritis admitted from February 2012 to October 2013 in the south hospital of Yongzhou Central Hospital were randomly divided into two groups. The control group was given routine treatment. The study group was given low-dose hormone Combination of mycophenolate mofetil and tripterygium glycosides treatment, the efficacy of the two groups in-depth comparison. Results The total effective rate of the study group was 91.2%, significantly higher than that of the control group (70.6%), the difference was statistically significant (P <0.05). The disappearance time of proteinuria, hematuria, edema and hypertension in the study group was significantly shorter than that in the control group (P <0.01). Conclusion The combination of low-dose hormones with mycophenolate mofetil and tripterygium glycosides in the treatment of children’s purpuric nephritis has obvious curative effect, which is good for improving the symptoms of patients and has good safety. It is worth popularizing and applying.