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目的分析对慢性阻塞性肺疾病合并肺动脉高压患者行华法林治疗的疗效。方法择取巩义市人民医院收治的32例慢性阻塞性肺疾病合并肺动脉高压患者为对象进行研究,根据就诊时间随机分组。对照组16例,进行常规治疗,同时行低分子肝素静脉滴注;观察组16例,在常规治疗的基础上加用华法林治疗。结果治疗后观察组患者的收缩期肺动脉压水平明显低于治疗前,且治疗后低于同期对照组(P均<0.05);治疗后两组患者动脉二氧化碳分压及动脉氧分压水平均优于治疗前,观察组改善情况优于对照组(P<0.05);观察组患者的呼吸困难改善时间明显短于对照组,两组比较差异有统计学意义(P<0.05)。结论华法林治疗慢性阻塞性肺疾病合并肺动脉高压效果明显,值得临床重视和推广应用。
Objective To analyze the effect of warfarin on patients with chronic obstructive pulmonary disease and pulmonary hypertension. Methods 32 patients with chronic obstructive pulmonary disease and pulmonary hypertension treated in Gongyi Municipal People’s Hospital were selected as subjects, and randomly divided into groups according to the time of treatment. Control group of 16 patients, routine treatment, while low-molecular-weight heparin intravenous infusion; observation group of 16 patients on the basis of conventional treatment with warfarin therapy. Results After treatment, the systolic pulmonary arterial pressure in the observation group was significantly lower than that before treatment and after treatment was lower than that in the control group (P <0.05). After treatment, arterial carbon dioxide partial pressure and arterial oxygen partial pressure were both excellent Before treatment, the improvement in the observation group was better than that in the control group (P <0.05). The improvement of breathlessness in the observation group was significantly shorter than that in the control group. There was significant difference between the two groups (P <0.05). Conclusion warfarin treatment of chronic obstructive pulmonary disease with pulmonary hypertension has obvious effect, it is worth clinical attention and promotion.