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目的:检测白细胞介素27(IL-27)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中的表达,探讨其与OSCC临床病理因素的相关性。方法:应用酶联免疫反应(enzyme-linked immunosorbent assay,ELISA)检测40例OSCC患者和20例健康体检者血清中的IL-27水平。采用SPSS10.0软件包对检测数据进行t检验。结果 :OSCC患者血清中IL-27水平显著高于对照组(P<0.05),临床Ⅲ、Ⅳ期OSCC患者血清中IL-27水平显著高于Ⅰ、Ⅱ期患者(P<0.05);有颈淋巴结转移患者,血清IL-27水平显著高于无转移者(P<0.05)。结论:血清IL-27水平与口腔鳞状细胞癌的病理分级、临床分期及颈淋巴结转移密切相关。
Objective: To detect the expression of interleukin-27 (IL-27) in the serum of patients with oral squamous cell carcinoma (OSCC) and to explore its correlation with the clinicopathological factors of OSCC. Methods: Serum levels of IL-27 in 40 OSCC patients and 20 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA). Using SPSS10.0 software package to test the data t test. Results: Serum levels of IL-27 in patients with OSCC were significantly higher than those in controls (P <0.05). Levels of serum IL-27 in patients with stage III and IV OSCC were significantly higher than those in patients with stage I and II (P <0.05) Patients with lymph node metastasis, serum IL-27 levels were significantly higher than those without metastasis (P <0.05). Conclusion: Serum IL-27 level is closely related to the pathological grade, clinical stage and cervical lymph node metastasis in oral squamous cell carcinoma.