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目的:探讨联合应用洋金花和葡萄糖-胰岛素-钾(GIK)极化液治疗病态窦房结综合征(SSS)的疗效。方法:100例SSS患者随机分为两组,治疗组68例,洋金花散剂0.3g,口服,每日1次,10%葡萄糖500 ml+胰岛素8u+10%氯化钾10mL静脉滴注,每日1次,共计14 d;对照组32例仅行上述极化液静脉滴注治疗。于治疗前和治疗后分别行24 h动态心电图及食管电生理检查。结果:治疗后,治疗组平均心率、24 h总心率和对照组相比差异有显著性(P<0.01);窦房结恢复时间(SNRT)、校正后窦房结恢复时间(cSNRT)和窦房传导时间(SACT)和对照组相比有显著性差异(P<0.01)。结论:联合应用洋金花和CIK极化液治疗病态窦房结综合征是一种安全有效的方法。
Objective: To investigate the curative effect of combined application of Pseudostellaria nivalis and glucose-insulin-potassium (GIK) in the treatment of sick sinus syndrome (SSS). Methods: One hundred patients with SSS were randomly divided into two groups. The treatment group (n = 68), Yangjinhua powder 0.3g, orally, once daily, 10% glucose 500ml + insulin 8u + 10% potassium chloride 10mL Day 1, a total of 14 d; control group, 32 cases only the above intravenous infusion of polarized solution. Before treatment and after treatment, 24 h dynamic electrocardiogram and esophageal electrophysiological examination. Results: After treatment, the average heart rate and the total heart rate at 24 h were significantly different from those in the control group (P <0.01); the recovery time of sinus node (SNRT), corrected sinus node recovery time (cSNRT) and sinus Atrial conduction time (SACT) compared with the control group were significantly different (P <0.01). CONCLUSION: Combined application of Pseudostellaria nigra and CIK Polarization in the treatment of sick sinus syndrome is a safe and effective method.