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目的:比较应用α-硫辛酸抗氧化应激治疗联合胰岛素强化降糖对初诊2型糖尿病患者胰岛β细胞功能的影响。方法:将104例初诊2型糖尿病患者随机分为联合组、单药组两组,分别给予α-硫辛酸联合胰岛素强化治疗及单独胰岛素强化治疗12周,比较两组患者治疗前后口服葡萄糖耐量试验(OGTT)、C肽释放试验各时间点血浆葡萄糖、C肽及胰岛功能相关指标的变化。结果:联合组OGTT试验1小时血糖(1 h PG)、2小时血糖(2 h PG)、3小时血糖(3 h PG)较单药组明显下降,空腹C肽(FCP)、0.5小时C肽(0.5 h CP)、2小时C肽(2 h CP)水平较单药组明显升高,胰岛β细胞功能指数[HOMA-β(CP)]、糖负荷0.5 h时净增C肽与净增血糖比值(△CP30/△Glu30)、C肽曲线下面积(AUCC)与血糖曲线下面积(AUCG)比值(AUCG/AUCC)较单药组明显升高,差异均有统计学意义(P<0.05)。结论:α-硫辛酸联合胰岛素强化治疗较单独胰岛素强化治疗能够更好的恢复胰岛β细胞功能。
OBJECTIVE: To compare the effects of α-lipoic acid and anti-oxidative stress therapy on insulin resistance β-cell function in newly diagnosed type 2 diabetic patients. Methods: A total of 104 patients with newly diagnosed type 2 diabetes mellitus were randomly divided into combined group and single drug group. Patients were given α-lipoic acid combined with intensive insulin therapy and insulin alone for 12 weeks respectively. Before and after treatment, oral glucose tolerance test (OGTT), C-peptide release test at various time points of plasma glucose, C-peptide and islet function-related indicators of change. Results: The blood glucose (1 h PG), 2 h PG (2 h PG), 3 h PG (3 h PG) in the OGTT group were significantly lower than those in the control group (P <0.05) (0.5 h CP) and 2 h C peptide (2 h CP) were significantly higher than those in the single drug group (P <0.05). HOMA-β (CP) The ratio of AUCC to AUCG (AUCG / AUCC) was significantly higher than that of the single drug group (P <0.05), and the ratio of blood glucose (△ CP30 / △ Glu30) ). CONCLUSION: Alpha-lipoic acid combined with insulin-intensive therapy can restore islet β-cell function better than intensive insulin therapy alone.