血液恶性疾病或肝移植患儿并发真菌感染(大多为念珠菌或曲霉感染 )已成为发病率及死亡率不断上升的原因。伊曲康唑为一广谱抗真菌药物 ,在体外有抗曲霉活性 ,可用于预防和治疗免疫功能低下儿童粘膜及侵入性真菌感染。由于婴儿和儿童服用胶囊有困难 ,为方便给药 ,作者开发了以羟 Fungal infections (mostly Candida or Aspergillus infections) in children with hematologic malignancies or liver transplants have become a cause of morbidity and mortality. Itraconazole is a broad-spectrum antifungal agent that has anti-Aspergillus activity in vitro and can be used to prevent and treat mucosal and invasive fungal infections in immunocompromised children. Due to the difficulty of taking capsules in infants and children, the authors developed hydroxy for ease of administration