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目的本试验旨在通过测定慢性心衰患者血浆尾加压素II(urotensinⅡ,UⅡ)含量,分析其在慢性心衰患者诊断和治疗中的意义。方法采用放免法测定20例正常人和76例慢性心衰患者UII水平。结果慢性心衰患者UⅡ水平明显低于对照组(2.65±0.73pg/mlvs5.23±0.85pg/ml,P<0.05),UⅡ水平与心衰严重程度负相关(r=-0.743,P<0.001)。结论UII含量能反映慢性心衰的病情严重程度,可作为诊断慢性心衰及评价其严重程度的指标。
Objective This study aimed to determine the content of urotensin Ⅱ (UⅡ) in patients with chronic heart failure and analyze its significance in the diagnosis and treatment of patients with chronic heart failure. Methods UII levels were determined by radioimmunoassay in 20 normal subjects and 76 chronic heart failure patients. Results The level of UⅡ in patients with chronic heart failure was significantly lower than that in the control group (2.65 ± 0.73pg / ml vs5.23 ± 0.85pg / ml, P <0.05). The level of UⅡ was negatively correlated with the severity of heart failure (r = -0.743, P <0.001) ). Conclusion The content of UII can reflect the severity of chronic heart failure, which can be used as an index to diagnose chronic heart failure and evaluate its severity.