论文部分内容阅读
沉默信息调节因子3(sirt3)是线粒体烟碱腺嘌呤二核苷酸(NAD)依赖的去乙酰化蛋白,是调节线粒体代谢关键酶,可维持细胞内稳态平衡,在线粒体氧化代谢、能量代谢、信号调节和细胞凋亡等活动中发挥重要作用。sirt3是重要的凋亡调节因子,调节线粒体生物学效应和氧化应激水平,抵抗神经元细胞凋亡,其缺失可引起线粒体代谢异常和细胞损伤,甚至引起细胞凋亡。笔者综述了sirt3在线粒体三羧酸循环(TCA)、脂肪酸氧化等代谢活动和细胞凋亡中的重要作用,阐明sirt3可以维持线粒体的正常代谢活动,抵抗细胞凋亡,为肿瘤等疾病的研究提供重要靶点。
Sirt3 is a mitochondrial adenine dinucleotide (NAD) -dependent deacetylated protein that regulates mitochondrial metabolism and maintains homeostasis, mitochondrial oxidative metabolism and energy metabolism , Signal regulation and apoptosis and other activities play an important role. Sirt3 is an important regulator of apoptosis, which regulates the biological effects of mitochondria and the level of oxidative stress, and resists the apoptosis of neurons. The deletion of sirt3 can cause the abnormal metabolism of mitochondria and cell damage, and even lead to apoptosis. This review summarizes the important role of sirt3 in metabolic activity and apoptosis such as mitochondrial TCA, fatty acid oxidation, and so on. It is demonstrated that sirt3 can maintain normal mitochondrial metabolism and resist cell apoptosis and provide a basis for the research of oncology and other diseases Important target.