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目的 检测食管癌放疗前后 DNA含量的改变及其对预后的影响 ,并评价食管癌治疗后生存率。方法 对 5 2例可根治的胸中段食管鳞状细胞癌行术前放疗 ,并行根治性切除术。两野对穿照射 ,肿瘤剂量 30～ 40 Gy/15～ 2 0次 ,3～ 4周 ,ICM分析 DNA倍体和 DNA含量。结果 放疗前、后异倍体率分别为 89.4%和 76 .7% ;放疗后DNA倍体和 DNA含量对预后均有明显影响 (P=0 .0 1) ;放疗使 DAN含量明显下降 (P=0 .0 0 2 ) ,而 DNA倍体变化不明显 (P=0 .2 0 83)。结论 活检标本 DNA含量检测对评估预后的价值可能不大 ,手术标本 DNA含量能够明确地预示生存率 ,放疗引起 DNA含量显著下降 ,而对倍体的影响不明显。
Objective To detect the change of DNA content in esophageal cancer before and after radiotherapy and its effect on prognosis, and to evaluate the survival rate of esophageal cancer after treatment. Methods Radiotherapy was performed in 52 cases of moderate and advanced esophageal squamous cell carcinoma of the esophagus, and radical resection was performed. Two wild to wear radiation, the tumor dose 30 ~ 40 Gy / 15 ~ 20 times, 3 to 4 weeks, ICM analysis of DNA ploidy and DNA content. Results Before and after radiotherapy, the rates of aneuploidy were 89.4% and 76.7% respectively. DNA ploidy and DNA content had significant effects on the prognosis (P = 0.01) after radiotherapy. The radiotherapy decreased the content of DNA (P = 0 .0 0 2), while DNA ploidy did not change significantly (P = 0.2203). Conclusions The DNA content of biopsy specimens may not be of great value in assessing the prognosis. The DNA content of the surgical specimens can clearly predict the survival rate and the DNA content of radiotherapy causes a significant decrease, while the effect on the ploidy is insignificant.