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碱性成纤维细胞生长因子是促进神经干细胞增殖的重要细胞因子,通过与靶细胞表面特异性酪氨酸激酶跨膜受体结合,促进神经干细胞增殖,推迟其分化,维持干细胞及其后裔细胞的存活,碱性成纤维细胞生长因子的撤退可触发神经干细胞分化。视黄酸(RA)是一种调节神经系统发育的重要营养素,通过核受体或直接通过RA反应元件调节细胞的基因表达。RA可加强干细胞向神经元、星形胶质细胞方向分化,而抑制其向少突胶质细胞方向分化。
Basic fibroblast growth factor is an important cytokine that promotes the proliferation of neural stem cells. It promotes the proliferation of neural stem cells by binding to the surface-specific tyrosine kinase transmembrane receptors on the target cells, delaying their differentiation, and maintaining the stem cells and their descendant cells Survival, withdrawal of basic fibroblast growth factor can trigger neural stem cell differentiation. Retinoic acid (RA) is an important nutrient that regulates the development of the nervous system and regulates the gene expression of cells through nuclear receptors or directly through RA-responsive elements. RA can enhance the stem cells to neurons, astrocytes in the direction of differentiation, and inhibit its direction to oligodendrocyte differentiation.