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大量文献报道,高迁移率族蛋白B1(HMGB1)在炎症性疾病的发病机理中发挥着重要的作用。近年来,对于HMGB1是否也参与了缺血再灌注介导的炎性损伤,引起了学者更为广泛的关注。本文就其在缺血再灌注损伤中的作用的研究进展进行了综述。
A large number of literatures reported that high mobility group box 1 (HMGB1) plays an important role in the pathogenesis of inflammatory diseases. In recent years, whether HMGB1 is also involved in the inflammatory injury induced by ischemia-reperfusion has aroused a more widespread concern. This article reviews its progress in the role of ischemia-reperfusion injury.