近来发现遗传变异而表达单纯疱疹病毒胸苷激酶基因(HSV—tk)的肿瘤细胞在小鼠体内有杀伤肿瘤细胞效果。据证实,这些细胞在接触丙氧鸟苷(GCV)后可能对未经处理过之“旁观者”(Bystander)肿瘤细胞有杀伤效应,而且HSV—tk基因阳性肿瘤细胞对未经转导过之肿瘤细胞之杀伤作用取决于小鼠体内完整的免疫系统。目前正在进行的研究分析了在注射HSV—tk基因转导细胞进入小鼠体内后发生的宿主抗肿瘤免疫反应。该研究用BALB/C小鼠,在第0天,通过向其 Recently, tumor cells that have been genetically altered to express the herpes simplex virus thymidine kinase gene (HSV-tk) have been shown to kill tumor cells in mice. It has been confirmed that these cells may have a killing effect on untreated “bystander” tumor cells after exposure to GCV, and that HSV-tk positive tumor cells have not been transduced. The killing effect of tumor cells depends on the intact immune system in mice. Research is currently ongoing to analyze the host antitumor immune response that occurs after injection of HSV-tk transduced cells into mice. The study used BALB/C mice on day 0 through