虽然慢性或亚慢性接触DON的资料不多,但有些中毒症状提示,胃肠功能紊乱可能与之有关。本实验采用平均体重18 g的80只雄性小鼠,饲养1周后随机分8组(每组10只),做2个实验,每个实验4组动物,分别饲以含DON0,0.1,1,10 mg/kg的饲料6周。每3天称重一次,记录每组饲料消耗量。饲养期结束时处死动物,取空肠段8 cm,用卡波金(95％O_2:5％CO_2)饱和的、碳酸氢盐缓冲的Tyrodc液(37℃,pH7.2)灌注。灌液静水压16 cmH_2O, Although there is not much data on chronic or subchronic exposure to DON, some symptoms of poisoning suggest that gastrointestinal disorders may be involved. In this study, 80 male mice weighing 18 g were randomly divided into 8 groups (10 in each group) after 1 week of feeding. Two experiments were performed. Four animals in each experiment were fed with DON0, , 10 mg / kg feed for 6 weeks. Weigh every 3 days and record the consumption of each group of feed. The animals were sacrificed at the end of the feeding period, and the jejunum segment was harvested at 8 cm and perfused with bicarbonate buffered Tyrodc solution (37 ° C, pH 7.2) saturated with carbopol (95% O 2: 5% CO 2). Hydrostatic pressure of irrigation fluid 16 cmH_2O,