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目的探讨四联疗法治疗幽门螺杆菌感染引起的胃溃疡疾病的临床效果。方法选择2010年1月至2013年1月于嵩县中医院就诊、经检查确诊为幽门螺杆菌感染引起的胃溃疡患者112例,随机分为对照组和观察组各56例;对照组按照传统方法给予三联疗法,观察组给予四联疗法。结果对照组总有效率为82.14%;观察组总有效率为94.64%。两组患者疗效相比差异有统计学意义(χ2=4.264,P<0.05);对照组幽门螺杆菌清除率为71.43%,观察组幽门螺杆菌清除率为87.50%,两者相比差异有统计学意义(χ2=4.432,P<0.05)。结论四联疗法能够提高幽门螺杆菌的根治率,值得临床推广运用。
Objective To investigate the clinical effect of quadruple therapy on gastric ulcer caused by Helicobacter pylori infection. Methods One hundred and twelve patients with gastric ulcer caused by Helicobacter pylori infection diagnosed in Song County Chinese Medicine Hospital from January 2010 to January 2013 were randomly divided into control group and observation group with 56 cases each. Methods triple therapy, observation group given quadruple therapy. Results The total effective rate of the control group was 82.14%; the total effective rate of the observation group was 94.64%. The difference between the two groups was statistically significant (χ2 = 4.264, P <0.05); control group H. pylori clearance rate was 71.43%, the observation group H. pylori clearance rate was 87.50%, the difference between the two statistics Significance (χ2 = 4.432, P <0.05). Conclusion Quadruple therapy can improve the cure rate of Helicobacter pylori, which is worthy of clinical application.