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目的 1.研究重组牛碱性成纤维细胞生长因子眼用凝胶(贝复舒眼用凝胶)在翼状胬肉术后对角膜上皮修复的影响。2.探讨贝复舒眼用凝胶对翼状胬肉复发率的影响。方法 2008年6～9月室收治的翼状胬肉病例80例(80眼),随机分为治疗组和对照组。两组均为同一术者显微镜下行翼状胬肉切除联合角膜缘干细胞移植术,术后两组均常规护理,治疗组采用贝复舒眼用凝胶和氧氟沙星滴眼液点眼,对照组采用氧氟沙星滴眼液点眼。滴眼后24 h,48 h,72 h,96 h,120 h,144 h,168 h观察患者的角膜上皮愈合情况;随访观察术后3个月,6个月,12个月,18个月患者翼状胬肉的复发情况。结果治疗组角膜上皮愈合较快,两组角膜上皮痊愈时间比较有显著性差异(t=5.331,p<0.05)。术后18个月治疗组和对照组的复发率比较没有统计学差异(χ2=0.28,P>0.05)。结论贝复舒眼用凝胶能很好地促进角膜上皮细胞的再生和修复,有效减轻患者术后的不适症状。
Objective 1. To study the effect of recombinant bovine basic fibroblast growth factor ophthalmic gel on the repair of corneal epithelium after pterygium surgery. To investigate the influence of Beifu Shu eye gel on the recurrence rate of pterygium. Methods 80 cases (80 eyes) of pterygium admitted from June to September in 2008 were randomly divided into treatment group and control group. Both groups were the same surgeon under the microscope pterygium excision combined with limbal stem cell transplantation, postoperative two groups were routine care, the treatment group with Beifu Shu eye gel and ofloxacin eye drops, the control group Ofloxacin eye drops. Corneal epithelial healing was observed at 24 h, 48 h, 72 h, 96 h, 120 h, 144 h, 168 h after the instillation. The follow-up observation included 3 months, 6 months, 12 months and 18 months Patients with recurrence of pterygium. Results The corneal epithelium healed rapidly in the treatment group, and the corneal epithelial healing time was significantly different between the two groups (t = 5.331, p <0.05). There was no significant difference in relapse rate between the treatment group and the control group 18 months after surgery (χ2 = 0.28, P> 0.05). Conclusion Beifu Shu eyes gel can well promote the regeneration of corneal epithelial cells and repair, effectively reduce the patient’s postoperative symptoms.