原发性肝癌是我国常见的恶性肿瘤之一,由于起病隐匿,早期诊断率低,绝大多数患者在确诊时已达中晚期,失去了手术时机,其中很多病例也不符合肝动脉栓塞化疗(TA-CE)的指征,或TACE后复发转移,对此类患者可行全身的姑息化疗。但目前常用药物和方案疗效差或无效,也尚无统一规范治疗方 Primary liver cancer is one of the most common malignant tumors in our country. Because of its insidious onset and low early diagnosis rate, the vast majority of patients have reached the advanced stage at the time of diagnosis and have lost the opportunity for surgery. Many of these cases also do not meet the requirements of hepatic arterial chemoembolization (TA-CE), or recurrence and metastasis after TACE, palliative chemotherapy for these patients is feasible systemic. However, the commonly used drugs and programs are poor or ineffective, there is no uniform standardized treatment