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[目的]研究白芍总苷(TGP)对肠易激综合征(IBS)大鼠Th1/Th2细胞因子的影响。[方法]实验动物按随机数字表法分为5组:模型组、TGP高剂量组、TGP低剂量组、阳性对照组、正常组;除正常组外,其他各组采用免疫诱导联合心理应激法建立IBS大鼠模型。观察各组大鼠血清及结肠黏膜Th1细胞因子白细胞介素(IL)-2、Th2细胞因子IL-5水平的变化。[结果]与正常组比较,模型组大鼠血清、结肠黏膜IL-2水平明显增高(P<0.01),IL-5水平降低(P<0.05);与模型组比较,TGP高、低剂量组及阳性对照组血清、结肠黏膜IL-2水平明显降低(P<0.05,0.01),IL-5水平增高(P<0.05)。[结论]IBS大鼠血清、结肠黏膜Th1/Th2表达失衡,TGP有调节平衡的作用。
[Objective] To investigate the effect of total glucosides of paeony (TGP) on Th1 / Th2 cytokines in rats with irritable bowel syndrome (IBS). [Methods] The experimental animals were randomly divided into five groups according to random number table: model group, TGP high dose group, TGP low dose group, positive control group and normal group; except the normal group, the other groups were induced by immune induction combined with psychological stress Method to establish IBS rat model. The changes of Th1 cytokine interleukin (IL) -2 and Th2 cytokine IL-5 in serum and colonic mucosa of rats in each group were observed. [Results] The levels of IL-2 in serum and colonic mucosa in model group were significantly higher than those in normal group (P <0.01), while the levels of IL-5 were decreased (P <0.05). Compared with model group, (P <0.05, 0.01), IL-5 level increased (P <0.05) .Conclusion: 1. [Conclusion] The expression of Th1 / Th2 in serum and colonic mucosa of IBS rats is unbalanced, and TGP plays a role of regulating the balance.