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作者研究了联甲苯胺(DMBZ)的尿液中代谢产物及其致突变性。实验用12周龄左右体重约300g的Sprague-Dawley系雄性大鼠,实验组与对照组各4只。将联甲苯胺混悬于阿拉伯胶中,按50mg/kg喂饲大鼠,收集停食24小时内的尿液,调pH至7,用乙醚提取后做为实验样品。以未饲化学物质的大鼠尿液乙醚提取物作对照。将联甲苯胺、乙酰联苯胺N-AcBz、二乙酰联苯胺(N,N′-AcBZ)二甲乙酰联苯胺(N-AcDMBZ)二甲基二乙酰联苯胺(N,N′-AcDMBZ)以及上述尿液提取物均用二甲亚砜溶
The authors studied the urinary metabolites and their mutagenicity of tolidine (DMBZ). Sprague-Dawley male rats weighing 12 weeks and weighing about 300 g were used in the experiment, 4 in each experimental and control group. The tolidine was suspended in gum arabic, according to 50mg / kg rats were fed, collected within 24 hours of urine urine, adjusted to pH 7, extracted with ether as an experimental sample. Rats with no chemical substances in urine ether extract as a control. Acetodipine N-AcBz, diacetyldibenzidine (N, N’-AcBZ) dimethylacetamide (N-AcDMBZ) dimethyldiacetylbenzidine (N, N’-AcDMBZ) The urine extract was dissolved in dimethyl sulfoxide