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Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH ) and GnRH antagonists for IVF. Design Prospective, randomized, controlled trial . Setting Tertiary referral center. Patient(s) Four hundred thirteen patients un dergoing IVF. Intervention(s) Rec-FSH stimulation starting on day 2 of the cycl e combinedwith daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three fol licles were ≥17 mm on ultrasound (early-hCG group, 208 patients) or 2 days lat er after this criterion was met (late-hCG group, 205 patients). Main outcome me asure(s) Ongoing pregnancy rate. Result(s) Fertilization rates and number and qu ality of embryos transferred did not differ between the two groups. However, a s ignificantly lower ongoing pregnancy rate was present in the late-hCG as compar ed with the early-hCG group (25.0%vs. 35.6%, respectively). Conclusion(s) Pro longation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated w ith a significantly lower ongoing pregnancy rate.
Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF. Design Prospective, randomized, controlled trial. Setting Tertiary referral center. Patient (s) Four hundred thirteen patients un dergoing IVF. Intervention (s) Rec-FSH stimulation starting on day 2 of the cycl e combinedwith daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three fol licles were> 17 mm on ultrasound (early-hCG group, 208 patients) or 2 days lat er after this criterion was met (late-hCG group, 205 patients). Main outcome me asure (s) Ongoing pregnancy Result (s) Fertilization rates and number and quity of embryos transferred did not differ between the two groups. However, as ignificantly lower ongoing pregnancy rate was present in the late-hCG as compar ed with the early-hCG group (25.0 % vs . Conclusion (s) Pro longation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated w ith a significantly lower ongoing pregnancy rate.