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目的:探讨养血调肝方对去卵巢大鼠模型骨密度及骨代谢方面的影响。方法:将雌性6月龄健康wistar大鼠70只随机分为假手术组、模型组、尼尔雌醇组、六味地黄丸组、养血调肝方大、中、小剂量组。用药4个月后检测各组大鼠骨密度、骨矿含量及血清骨钙素、碱性磷酸酶、抗酒石酸酸性磷酸酶、尿脱氧吡啶酚。结果:养血调肝方能明显地增加去卵巢后大鼠骨密度、骨矿含量;升高去卵巢大鼠血清骨钙素、碱性磷酸酶水平,或降低血清抗酒石酸酸性磷酸酶和尿脱氧吡啶酚水平。结论:养血调肝方能通过促进骨形成或抑制骨吸收增加骨密度、骨矿含量,从而对绝经后骨质疏松症有一定的防治作用。
Objective: To investigate the effect of Yangxue Tiaogan Recipe on bone mineral density and bone metabolism in ovariectomized rat models. METHODS: Seventy female six-month-old healthy wistar rats were randomly divided into sham-operated group, model group, nilestriol group, Liuwei Dihuang Wan group and nourishing tonifying liver prescription group. After 4 months of treatment, bone mineral density, bone mineral content, and serum osteocalcin, alkaline phosphatase, tartrate-resistant acid phosphatase, and urinary deoxypyridinoline were measured in each group. Results: Yangxue Tiaogan Recipe can significantly increase bone mineral density and bone mineral content in ovariectomized rats; increase serum levels of osteocalcin and alkaline phosphatase in ovariectomized rats, or decrease serum tartrate-resistant acid phosphatase and urine Deoxypyridinoline levels. Conclusion: Yangxue Tiaogan Fang can increase the bone density and bone mineral content by promoting bone formation or inhibiting bone resorption, thus it can prevent and treat postmenopausal osteoporosis.