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目的 :检测术前乳腺癌患者血清中T PSA和F PSA的含量 ,探讨其和乳腺癌临床生物学行为的关系及在诊断中的价值。方法 :利用微粒子酶免分析法 ,检测 85名女性乳腺癌患者和 30名健康女性血清中T PSA和F PSA的含量。结果 :指标的最低检测值为 0 .0 1ng/ml。乳腺癌患者血清中F PSA水平明显高于健康女性 (P <0 .0 5 ) ,F PSA优势患者占 3.76 % ,而健康女性中仅占 3.3%。T PSA和F PSA的阳性判断值 (cut offvalue)分别为 0 .36ng/ml和0 .0 2ng/ml,女性乳腺癌患者的T PSA和F PSA阳性率分别为 2 3.5 %和 2 7.1%。T PSA阳性患者中 ,淋巴结转移者较多 (70 % ,P >0 .0 5 ) ,而F PSA优势患者中 ,早期 (Ⅰ、Ⅱ期 )发病率较高 (6 8.8% ,P >0 .0 5 )。结论 :虽然F PSA占优势鉴别乳腺癌的敏感性较低 ,但特异性较高。早期乳腺癌有F PSA占优势的趋势。血清检测T PSA和F PSA对乳腺癌的诊断及预后判断有一定意义
Objective: To detect the contents of T PSA and F PSA in the serum of patients with preoperative breast cancer and to explore its relationship with the clinical biological behavior of breast cancer and its value in the diagnosis. Methods: The levels of T-PSA and F-PSA in sera of 85 female breast cancer patients and 30 healthy women were detected by particle enzyme immunoassay. Results: The minimum value of the indicator was 0. 01ng / ml. The level of F PSA in serum of breast cancer patients was significantly higher than that in healthy women (P <0.05), 3.76% in F PSA predominant patients, and only 3.3% in healthy women. The positive cutoff values of T PSA and F PSA were 0.36 ng / ml and 0.2 ng / ml, respectively. The positive rates of T PSA and F PSA in female breast cancer patients were 23.5% and 21.7%, respectively. Among the T PSA positive patients, there were more lymph node metastases (70%, P> 0.05), while the patients with F PSA predominance had a higher incidence of early stage Ⅰ and Ⅱ (68.8%, P> 0). 0 5). Conclusion: Although F PSA is predominantly susceptible to breast cancer, its sensitivity is low but its specificity is high. Early breast cancer has the trend of F PSA predominance. Serum detection of T PSA and F PSA for breast cancer diagnosis and prognosis of a certain significance