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检测了伴或不伴水钠潴留慢性肾炎患者血浆内皮素（ｐＥＴ）和２４ｈ尿蛋白排泄量。结果发现，水钠潴留组ｐＥＴ（１７２．４８±４５．７７μｇ／Ｌ）显著高于无水钠潴留组（１０２．３３±２２．８２μｇ／Ｌ，Ｐ＜０．０１）和对照组（９４．７５±２０．４８μｇ／Ｌ，ｐ＜０．０１）；２４ｈ尿蛋白排泄量，水钠潴留组显著高于无水钠潴留组（９．６２±７．２５ｇ／Ｌ２．７８±２．３３ｇ／Ｌ，Ｐ＜０．０１），但尿蛋白排泄量与ｐＥＴ水平无明显相关。提示ＥＴ可能参与了慢性肾炎水钠潴留的病理机理，并影响着慢性肾炎的病理发展。
Plasma endothelin (pET) and urinary protein excretion (24h) were measured in patients with or without sodium and water retention chronic nephritis. The results showed that pET (172.48 ± 45.77μg / L) in Shuinazhulian group was significantly higher than that in sodium-free water retention group (102.33 ± 22.82μg / L, P <0.01) and control group (94.3% 75 ± 20.48μg / L, p <0.01); 24h urinary protein excretion, Shuinazhuliu group was significantly higher than the anhydrous sodium retention group (9.62 ± 7.25g / L2.78 ± 2.33g / L, P <0.01), but there was no significant correlation between urinary protein excretion and pET level. It is suggested that ET may be involved in the pathological mechanism of Shuinazhulian chronic nephritis, and affect the pathological development of chronic nephritis.