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培美曲塞是一种多靶点的新型叶酸代谢拮抗剂,它通过抑制胸苷酸合成酶、二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶破坏细胞内叶酸依赖性代谢过程干扰细胞复制,从而抑制肿瘤生长。目前有关培美曲塞治疗包括恶性胸膜间皮细胞瘤、非小细胞肺癌、乳腺癌、胰腺癌、胃肠道肿瘤、头颈部肿瘤等多种恶性肿瘤的临床研究均有报道,本文综述培美曲塞单药或多药联合治疗在非小细胞肺癌的临床研究。
Pemetrexed is a multi-targeted, novel folate metabolic antagonist that disrupts intracellular folate-dependent metabolic processes by inhibiting thymidylate synthase, dihydrofolate reductase, and glycinamide nucleotidyl transferase Interfere with cell replication, thereby inhibiting tumor growth. Pemetrexed treatment of malignant pleural mesothelioma, non-small cell lung cancer, breast cancer, pancreatic cancer, gastrointestinal cancer, head and neck cancer and other malignancies have been reported in clinical studies. Clinical study of metribuzin or multidrug combination therapy in non-small cell lung cancer.