Objective: To observe clinical efficacy of acupuncture with cognitive training on motor function and activities of daily living (ADL) after ischemic stroke. Methods: A total of 68 patients with ischemic stroke in departments of neurology and rehabilitation medicine in Binzhou City People's Hospital of Shandong province from January 2015 to December 2019 were selected. They were randomly divided into the treatment group and the control group, with 34 cases in each group. The 2 groups were both given conventional medication and rehabilitation. The control group received cognitive training, while the treatment group was treated by acupuncture more. Fugl-Meyer Assessment Upper Extremity Scale (FMA-UE), Fugl-Meyer Assessment Lower Extremity Scale (FMA-LE), Modified Barthel Index (MBI) and Mini-mental State Examination (MMSE) were used to evaluate efficacy in the 2 groups respectively before the treatment, 2 months and 4 months after the treatment. Results: There was no statistically significant differences in FMA-UE, FMA-LE, MBI and MMSE scores between the 2 groups before the treatment (P>0.05). The scores of FMA-UE, FMA-LE, MBI and MMSE in the 2 groups were significantly improved 2 months and 4 months after the treatment (P<0.05). The efficacy in the treatment group was better than that in the control group. Conclusion: Acupuncture with cognitive training is beneficial to recovery of motor function and improvement of ADL after stroke. At the same time, it also confirms effectiveness of acupuncture on cognitive disorder.