论文部分内容阅读
呋喃双胺,化学名:反式β-(5-硝基-2-呋喃)-N-(2-哌啶乙基)丙烯酰胺(Ⅰ),是继呋喃丙胺(F-30066)之后又一具有较强杀日本血吸虫童虫与成虫的口服药物。其盐酸盐F-30385(Ⅱ),在治疗实验动物的日本血吸虫病时,有比呋喃丙胺更好的疗效。1964年曾在嘉兴等地进行小规模临床试用,因消化道副反应较重而中止。后改用其游离盐基——呋喃双胺(F-30642)的细粉,对小鼠血吸虫病的化疗指数为呋喃丙胺的两倍,在等疗效基础上对兔的肠粘膜刺激也比呋喃丙胺与F-30385为轻。以呋喃双胺肠溶片与敌百虫注射剂合用,在浙江、江苏
(F-30066) followed by furanpropylamine (F-30066), the chemical name: trans β- (5-nitro-2-furan) -N- With strong kill Schistosoma japonicum and adult worms oral medication. Its hydrochloride F-30385 (Ⅱ), in the treatment of experimental animals, schistosomiasis japonica, than furosemide better efficacy. In 1964 Jiaxing and other places in small-scale clinical trials, due to severe side effects of digestive tract suspension. After switching to its free base - furanamide (F-30642) of the fine powder, the chemotherapy index of mice schistosomiasis furan propylamine twice, on the basis of the same effect on rabbit intestinal stimulation than furan Propylamine is light with F-30385. Furanamide enteric-coated tablets and trichlorfon injections, in Zhejiang and Jiangsu