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目的探讨溃洁灌肠液治疗Ⅱ度放射性直肠炎的临床疗效。方法选取南京中医药大学第三附属医院肛肠科及肿瘤科2011年1月—2017年3月收治的Ⅱ度放射性直肠炎患者195例,随机分为A组、B组和C组,每组65例。A组患者给予单纯西药治疗,B组患者给予康复新+地塞米松灌肠治疗,C组患者给予溃洁灌肠液保留灌肠。比较3组患者的临床疗效,治疗前后症状(腹泻、腹痛、血便)积分及血液流变学指标[中性粒细胞计数(NE)、红细胞沉降率、C反应蛋白(CRP)、丙氨酸氨基转移酶(ALT)],并观察患者不良反应发生情况。结果 C组患者治疗总有效率高于A组和B组,B组患者治疗总有效率高于A组(P<0.05)。治疗前,3组患者腹泻、腹痛、血便积分比较,差异无统计学意义(P>0.05);治疗后,B组和C组患者腹泻、腹痛、血便积分低于A组,C组患者腹泻、腹痛、血便积分低于B组(P<0.05)。治疗前,3组患者NE、红细胞沉降率、CRP、ALT比较,差异无统计学意义(P>0.05)。治疗后,B组和C组患者NE、红细胞沉降率、CRP低于A组(P<0.05);C组患者NE、红细胞沉降率、CRP低于B组(P<0.05),3组患者ALT比较,差异无统计学意义(P>0.05)。3组患者均未出现严重不良反应。结论采用溃洁灌肠液治疗Ⅱ度放射性直肠炎的临床疗效确切,其可更有效改善患者的临床症状,安全有效。
Objective To investigate the clinical efficacy of Roujie enema in treating Ⅱ degree radiation proctitis. Methods A total of 195 patients with grade Ⅱ radiitis rectalitis admitted to Department of Anorectal Surgery and Oncology, the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from January 2011 to March 2017 were randomly divided into A, B and C groups example. Patients in group A were treated with western medicine alone, patients in group B received Kangfuxin + dexamethasone enema treatment, and patients in group C were given ulcer retention enema. The clinical curative effect, symptom (diarrhea, abdominal pain, bloody stool) score and hemorheology index (neutrophil count, erythrocyte sedimentation rate, CRP, Transferase (ALT)], and observed the occurrence of adverse reactions in patients. Results The total effective rate of treatment in group C was higher than that in group A and B, and the total effective rate in group B was higher than that in group A (P <0.05). Before treatment, there was no significant difference in diarrhea, abdominal pain and bloody stool score between the three groups (P> 0.05). After treatment, the scores of diarrhea, abdominal pain and bloody stool in group B and group C were lower than those in group A, Abdominal pain and bloody stool score were lower than those in group B (P <0.05). Before treatment, NE, erythrocyte sedimentation rate, CRP, ALT in three groups had no significant difference (P> 0.05). After treatment, NE, erythrocyte sedimentation rate and CRP in group B and group C were lower than those in group A (P <0.05); In group C, NE, erythrocyte sedimentation rate and CRP were lower than group B (P <0.05) The difference was not statistically significant (P> 0.05). No serious adverse reactions occurred in all three groups. Conclusions The clinical curative effect of using ulcer cleaning enema in the treatment of Ⅱ degree radiological proctitis is exact, which can effectively improve the clinical symptoms of patients and is safe and effective.