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目的探讨肺鳞癌组织中淋巴管密度和纵隔淋巴结转移的关系。方法肺鳞癌纵隔淋巴结无转移组22例,肺鳞癌纵隔淋巴结转移组18例,肺炎性假瘤组10例。用LYVE-1/CD34免疫组化双染色法区分淋巴管和血管并观察淋巴管内皮透明质酸受体-1(LYVE-1)蛋白表达的情况,并与手术纵隔淋巴结清扫病理结果相比较。结果肺鳞癌组织周边部淋巴管密度远大于内部和炎性假瘤组织。肺鳞癌组织内部淋巴管和炎性假瘤组织淋巴管密度相似。肺鳞癌组织周边部淋巴管密度纵隔淋巴结转移组大于无纵隔淋巴结转移组。肺鳞癌组织内部淋巴管密度纵隔淋巴结转移组和无纵隔淋巴结转移组相似。结论肺鳞癌组织淋巴管生成主要在周边部,肺鳞癌细胞主要经过原发灶周边部增生的淋巴管转移至纵隔淋巴结。
Objective To investigate the relationship between lymphatic vessel density and mediastinal lymph node metastasis in squamous cell carcinoma of the lung. Methods Twenty-two patients with lung squamous cell carcinoma without mediastinal lymph node metastasis, lung squamous cell carcinoma with mediastinal lymph node metastasis, 18 patients with pulmonary inflammatory pseudotumor group. The lymphatic vessels and blood vessels were differentiated by LYVE-1 / CD34 double staining, and the expression of LYVE-1 protein in lymphatic vessels was observed. The expression of LYVE-1 was compared with the pathological results of surgical mediastinal lymph node dissection. Results The density of lymphatic vessels around the lung squamous cell carcinoma tissues was much larger than that of internal and inflammatory pseudotumor tissues. The density of lymphatic vessels in lymphatic vessels and inflammatory pseudotumor tissues in squamous cell carcinoma tissues was similar. Lymphatic vessel density in mediastinal lymph node metastasis of lung squamous cell carcinoma was higher than that of non-mediastinal lymph node metastasis. Lung squamous cell carcinoma lymphatic density within the mediastinal lymph node metastasis group and no mediastinal lymph node metastasis group. Conclusion Lymphangiogenesis in squamous cell carcinoma of the lung is mainly in the peripheral part. The majority of lung squamous cell carcinoma metastasize to the mediastinal lymph nodes via the lymphatic vessels which proliferate mainly in the peribronchia of the primary tumor.