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目的探讨臂踝脉搏波速度(baPWV)与缺血性心血管病(ICVD)危险评估程度之间的关系。方法选择我院健康体检中心行健康体检者3 200例为研究对象,年龄35～64岁,测量身高、体质量、血压;检测空腹血糖、血脂和baPWV;询问有关病史和吸烟史。采用“国人ICVD 10年发病危险简易评估工具”对受检者进行ICVD 10年发病危险评估。以受检者10年ICVD发病绝对风险<5.0%、5.0%～、10.0%～、20.0%～,分别定为低危、中危、高危和极高危4组。分析不同年龄组危险程度的差异、不同危险程度组间baPWV的差异。将baPWV≥1 400 cm/s定为增快,比较各危险程度组baPWV增快检出率的差异;将受检者baPWV与其ICVD危险得分行相关分析。结果 35～组、45～组、55～64岁组危险度间差异有统计学意义(P<0.0001)。3个年龄组,低危受检者baPWV均值间差异有统计学意义(P<0.05),中危、高危和极高危受检者baPWV均值比较,差异均无统计学意义(P>0.05)。低危、中危、高危和极高危组的baPWV均值分别为(1 356±171)、(1 626±220)、(1 786±307)和(2 032±458)cm/s,组间差异有统计学意义(P<0.0001)。低危组baPWV增快率为35.9%(1 042/2 916),中危组为88.1%(182/202),高危组为91.9%(55/56),极高危组为100.0%(37/37),4个危险度组baPWV增快率间差异有统计学意义(P=0.0001)。baPWV值与ICVD危险评分间呈正相关(r=0.67,P=0.0001)。结论 baPWV与ICVD 10年发病危险度有密切关系,其增快可预测ICVD发病风险,有助于检出危险人群,值得推广应用。
Objective To investigate the relationship between brachial-ankle pulse wave velocity (baPWV) and risk assessment of ischemic cardiovascular disease (ICVD). Methods A total of 3 200 healthy physical examination subjects in our center were selected as study subjects, aged 35-64 years old. Height, body weight and blood pressure were measured. Fasting blood glucose, blood lipids and baPWV were measured. History and smoking history were also inquired. The “ICVD 10-year risk assessment of a simple Chinese people ” ICVD 10-year risk assessment of the subjects. The absolute risk of onset of ICVD in 10 years was less than 5.0%, 5.0% ~, 10.0% ~, 20.0% ~, respectively, which were defined as low risk, moderate risk, high risk and very high risk. Analysis of differences in the risk of different age groups, different risk groups baPWV differences. The baPWV≥1 400 cm / s was set as fast, and the differences of detection rate of baPWV between different risk groups were compared. The correlation between baPWV and ICVD risk score was analyzed. Results There were significant differences in the risk among 35 ~ 45, 55 ~ 64 group (P <0.0001). The difference of baPWV between the three age groups and the low-risk subjects was statistically significant (P <0.05). There was no significant difference in the mean of baPWV among the medium-risk, high-risk and high-risk subjects (P> 0.05). The mean baPWV of low risk, moderate risk, high risk and very high risk group were (1 356 ± 171), (1 626 ± 220), (1 786 ± 307) and (2 032 ± 458) cm / There was statistical significance (P <0.0001). The increase rate of baPWV was 35.9% (1042/2 916) in low risk group, 88.1% (182/202) in intermediate risk group, 91.9% (55/56) in high risk group and 100.0% (37.0% 37). There was a significant difference in the increase rate of baPWV between the four risk groups (P = 0.0001). There was a positive correlation between baPWV and ICVD risk score (r = 0.67, P = 0.0001). Conclusions baPWV is closely related to the 10-year risk of ICVD. The rapid increase of baPWV can predict the risk of ICVD and help identify dangerous people, which is worth popularizing and applying.