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采用自由基溶液聚合和连续的互穿网络技术,以氧化还原引发体系为引发剂、化学交联聚丙烯酸(PAA)和聚乙烯醇(PVA)制备了一系列PAA/PVA水凝胶膜。ATR-FTIR光谱表明,网络组成之间形成了新的相互作用的氢键,DSC分析表示网络组成具有良好的热力学相容性。膜在各种介质中的溶胀性质表明:因PAA的亲水性强于PVA,溶胀比随PAA的增多而提高。以阳离子化合物结晶紫为模板药物考察了在不同的pH缓冲溶液中的释放行为,结果表明,药物的释放能力可以通过改变体系的pH值加以调控。
A series of PAA / PVA hydrogel films were prepared by free radical polymerization and continuous interpenetrating network. Redox initiator system as initiator, chemically crosslinked polyacrylic acid (PAA) and polyvinyl alcohol (PVA) were prepared. ATR-FTIR spectroscopy showed that new hydrogen bonds were formed between the network components, and DSC analysis showed that the network components had good thermodynamic compatibility. The swelling properties of the membrane in various media show that the swelling ratio increases with the increase of PAA due to the stronger hydrophilicity of PAA than PVA. The cationic compound crystal violet as a template drug was investigated in different pH buffer solution release behavior, the results show that drug release ability can be changed by changing the pH of the system to be regulated.