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目的探讨早产儿视网膜病变(ROP)的临床转归。方法回顾性分析342例ROP筛查患儿的临床资料。结果 342例早产儿中检出ROP患儿49例(85眼),发生率为14.3%,患儿出生体重(1231±157)g,胎龄(29.1±1.6)周;ROP 1、2、3期病变分别为22、10、17例,未发现4、5期病变。6例患儿失访,23例病变自行消退,5例急进性后极部ROP患儿经玻璃体腔注射雷珠单抗治疗后病变消退,15例行激光手术者中5例曾重复激光治疗。除失访病例外,随访患儿ROP病变均消退,远期视力不受影响。结论防治ROP的关键是建立完善有效的ROP筛查制度,早发现、早治疗可改善ROP的预后,避免儿童盲的发生。
Objective To investigate the clinical outcome of retinopathy of prematurity (ROP). Methods Retrospective analysis of 342 cases of ROP screening clinical data. Results Among 342 preterm infants, 49 (85 eyes) were detected in ROP, the incidence rate was 14.3%, the birth weight (1231 ± 157) g and gestational age (29.1 ± 1.6) weeks; Period of lesions were 22,10,17 cases, no discovery of 4,5 lesions. Six patients were lost to follow-up, and 23 patients subsided on their own. Five patients with acute ROP at the extreme posterior part subsided after intravitreal injection of ranibizumab. Five of 15 patients who received laser surgery had repeated laser treatment. Except for cases of missing, follow-up of children with ROP lesions subsided, long-term vision is not affected. Conclusion The key to prevention and treatment of ROP is to establish a complete and effective ROP screening system. Early detection and early treatment can improve the prognosis of ROP and avoid the blindness of children.