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体外受精(IVF)技术中控制性超排卵(COH)使用了大量外源性激素如促性腺激素释放激素类似物、拮抗剂以及黄体生成激素(LH)和卵泡刺激素(FSH),刺激多个卵泡同时发育和成熟。外源性激素导致妇女血清雌激素、孕酮显著超过正常生理水平,异常的性激素环境对循环系统的影响首当其冲,卵巢过度刺激综合征(OHSS)的发生是一个普遍的现象,即说明经过COH治疗的妇女循环功能发生障碍。其中血液动力学因子、脂类、胰岛素样生长因子(IGF)、瘦素(leptin)、血管内皮生长因子(VEGF)、内皮素(ET)等与循环系统密切相关的体液因子的血清水平发生不同的变化,变化的程度以及持续时间对妇女循环功能造成正面或负面影响,综合分析上述体液因子的变化可以评价IVF-ET技术的安全性。
Controlled superovulation (COH) in in vitro fertilization (IVF) uses a number of exogenous hormones such as gonadotropin-releasing hormone analogs, antagonists, and luteinizing hormone (LH) and follicle stimulating hormone (FSH) to stimulate multiple follicles At the same time develop and mature. Exogenous hormones lead to women’s serum estrogen and progesterone significantly higher than the normal physiological level, the abnormal sex hormone environment bear the brunt of the circulatory system, the occurrence of ovarian hyperstimulation syndrome (OHSS) is a common phenomenon that COH-treated Women have circulatory disorders. Serum levels of humoral factors such as hemodynamics, lipids, insulin-like growth factor (IGF), leptin, vascular endothelial growth factor (VEGF) and endothelin (ET) are closely related to circulatory system The degree of change and duration have a positive or negative impact on women’s circulatory function. The safety of IVF-ET technique can be evaluated by comprehensively analyzing the changes of body fluid factors mentioned above.