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观察了顶体酶抑制剂（EGB）对小鼠致畸性影响、结果表明，EGB在7．5～30mg／kg剂量范围内，在妊娠小鼠致畸敏感期（6～15天），由阴道连续给药对孕鼠体重、孕鼠的生殖机能、平均胎鼠体重、身长、尾长和胎盘重均无明显影响，也未见外观、骨骼和内脏畸形。
The effects of acrosin inhibitor (EGB) on the teratogenicity of mice were observed. The results showed that in the dose range of 7.5 ~ 30mg / kg, EGB was induced by teratogenicity in pregnant mice (6 ~ 15 days) Continuous vaginal administration had no effect on body weight of pregnant rats, reproductive function of pregnant rats, average fetal rat body weight, body length, tail length and placental weight, nor appearance, skeletal and visceral malformations.