目的了解浙江北部地区药物性肝病的发病率、致害药物和临床表现。方法采用整群分层抽样法,调查浙北地区8所医院内科18 965例病人。结果发现药物性肝病165例,占0.87%。抗菌素、抗结核药引起肝损害所占比例最高,以纳差、腹胀表现为主。结论重在预防,应加强“药害”意识,尽量避免联合用药,以减少药物性肝病的发生。 Objective To understand the incidence of drug-induced liver disease in northern Zhejiang, drug-induced and clinical manifestations. Methods The cluster stratified sampling method was used to survey 18 965 patients in 8 hospitals in north Zhejiang. The results found that drug-induced liver disease in 165 cases, accounting for 0.87%. Antibiotics, anti-TB drugs cause the highest proportion of liver damage, with anorexia, abdominal distension performance-based. Conclusions Emphasis on prevention should strengthen the awareness of “drug injury”, try to avoid combination medication to reduce the incidence of drug-induced liver disease.